Human IL-37b Protein (ILB-HE037) Summary
Product Description |
Recombinant Human IL-37b Protein is expressed from E.coli without tag.It contains Val46~Asp218. |
Product Background |
IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses. IL-37 has five different isoforms, and IL-37b is the most biologically functional subtype. IL-37b Inhibits PGN Induced Cytokines and Chemokines via the Downregulation of Intracellular Nuclear Factor (NF)-κB, PI3K–Akt, and ERK1/2 Pathways. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human IL-37b Protein (ILB-HE037) Specifications/Details
Protein |
IL-37b |
Synonyms |
IL-1F7b; IL-HLa; FIL1 zeta; IL-1X; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; FIL1Z; IL1F7; IL1H4; IL1RP1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Val46~Asp218 |
Molecular Weight |
The protein has a predicted MW of 19.30 kDa same as Bis-Tris PAGE result. |
Product Tag |
No Tag |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in 20mM PB, 150mM NaCl, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Human IL-37b on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human IL-37b is greater than 90% as determined by SEC-HPLC. |
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