SEC-HPLC chromatogram showing dual peaks at 9.814 and 13.307 minutes, indicating molecular weight distribution and purity of the recombinant protein.
Human IL-37b Protein (ILB-HE037)
  • Express System: E.coli
  • Product Tag: No Tag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
  • Amino Acid Range: Val46~Asp218
Catalog #ILB-HE037
Regular price $346.50
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Human IL-37b Protein (ILB-HE037) Summary

Product Description

Recombinant Human IL-37b Protein is expressed from E.coli without tag.It contains Val46~Asp218.

Product Background

IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses. IL-37 has five different isoforms, and IL-37b is the most biologically functional subtype. IL-37b Inhibits PGN Induced Cytokines and Chemokines via the Downregulation of Intracellular Nuclear Factor (NF)-κB, PI3K–Akt, and ERK1/2 Pathways.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Human IL-37b Protein (ILB-HE037) Specifications/Details

Protein
IL-37b
Synonyms
IL-1F7b; IL-HLa; FIL1 zeta; IL-1X; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; FIL1Z; IL1F7; IL1H4; IL1RP1
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Val46~Asp218
Molecular Weight
The protein has a predicted MW of 19.30 kDa same as Bis-Tris PAGE result.

Product Tag

No Tag
Expression System
E.coli
Purity
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin
Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in 20mM PB, 150mM NaCl, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-37b on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human IL-37b on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-37b is greater than 90% as determined by SEC-HPLC. The purity of Human IL-37b is greater than 90% as determined by SEC-HPLC.
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