Human KIR2DL3 Protein (KIR-HM4L3)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: His22-His245

Catalog: KIR-HM4L3

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Product Description Recombinant Human KIR2DL3 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His22-His245.

Product Background

KIR2DL3 (2DL3, formerly NKAT2, designated CD158b2) is a 341 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig‑like receptor (KIR) family of molecules. KIRs are expressed on human CD56dim NK cells and T cell subsets, and regulate effector functions in the innate immune system.KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

Product Category

Recombinant Protein

Target

KIR2DL3
Synonyms cl-6; KIR2DL3; KIRCL23; KIR-K7b; KIR-K7c; MGC129943; NKAT; NKAT2; NKAT-2; NKAT2A; NK-receptor; p58; NKAT2GL183; CD158b; CD158B2; GL183; KIR-023GB; KIR2DS5; NKAT2B
Accession

Species

Human

Amino Acid Range

His22-His245
Molecular Weight The protein has a predicted MW of 27.3 kDa. Due to glycosylation, the protein migrates to 45-52 kDa based on Tris-Bis PAGE result.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human KIR2DL3 is greater than 95% as determined by SEC-HPLC.
Human KIR2DL3 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

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