Product Description |
Recombinant Human KIR2DL3 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His22-His245. |
Product Background |
KIR2DL3 (2DL3, formerly NKAT2, designated CD158b2) is a 341 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig‑like receptor (KIR) family of molecules. KIRs are expressed on human CD56dim NK cells and T cell subsets, and regulate effector functions in the innate immune system.KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. |
Product Category |
Recombinant Protein |
Target |
KIR2DL3 |
Synonyms |
cl-6; KIR2DL3; KIRCL23; KIR-K7b; KIR-K7c; NKAT; NKAT2; NKAT-2; NKAT2A; CD158b; CD158B2; GL183; KIR2DS5; NKAT2B |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
His22-His245 |
Molecular Weight |
The protein has a predicted MW of 27.3 kDa. Due to glycosylation, the protein migrates to 45-52 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human KIR2DL3 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. |
|
|
The purity of Human KIR2DL3 is greater than 95% as determined by SEC-HPLC. |
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