Name: Human LAIR1/CD305 Protein (LAI-HM4R1)
Brand: KactusBio
SKU: LAI-HM4R1-100UG
Price: 330.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human LAIR1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA (QC Test). The affinity constant of 0.082 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gln22-His163

Catalog #LAI-HM4R1

Size

100UG

500UG

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Product Description	Recombinant Human LAIR1/CD305 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gln22-His163.
Product Background	LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
Product Category	Recombinant Protein / Antibody discovery

Protein	LAIR1/CD305
Synonyms	CD305; HLAIR1; LAIR1; LAIR-1
Accession	Q6GTX8-1
Species	Human
Biotinylated	no
Amino Acid Range	Gln22-His163
Molecular Weight	The protein has a predicted MW of 18.2 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human LAIR1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA (QC Test). The affinity constant of 0.082 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human LAIR1, His Tag captured on CM5 Chip via Anti-His Antibody can bind Native Human Collagen I protein with an affinity constant of 0.082 nM as determined in SPR assay (Biacore T200).
	Immobilized Human LAIR1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA (QC Test).
	Human LAIR1 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
	The purity of Human LAIR1 is greater than 95% as determined by SEC-HPLC.