Name: Mouse&Human Chimeric Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-HM1V6)
Brand: KactusBio
SKU: ITG-HM1V6-100UG
Price: 375.0 USD
Availability: InStock

Mouse&Human Chimeric Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-HM1V6)

Immobilized Mouse&Human Chimeric ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His-Avi Tag with the EC50 of 36.8ng/ml determined by ELISA (QC Test).

Immobilized Human&Mouse Chimeric ITGAV&ITGB6, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human LAP (TGF beta 1), His Tag with the EC50 of 78.4ng/ml determined by ELISA.

Immobilized Mouse&Human Chimeric ITGAV&ITGB6, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGB6 Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA.

Mouse&Human Chimeric ITGAV&ITGB6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Mouse&Human Chimeric ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Mouse&Human Chimeric ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His-Avi Tag with the EC50 of 36.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Phe31-Val988(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail

Catalog #ITG-HM1V6

Size

100UG

500UG

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Product Description	Recombinant Mouse&Human Chimeric Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Phe31-Val988 (ITGAV) acidic tail and Gly22-Asn707 (ITGB6) basic tail.
Product Background	ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer
Synonyms	αVβ6; Integrin alpha V beta 6; ITGAV&ITGB6;Integrin alpha V β 6
Accession	P43406(ITGAV)&P18564-1(ITGB6)
Species	Mouse&Human
Biotinylated	no
Amino Acid Range	Phe31-Val988(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail
Molecular Weight	The protein has a predicted MW of 131.48 kDa (ITGAV) and 79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 120-160 kDa (ITGAV) and 90-120 kDa (ITGB6) based on Bis-Tris PAGE result.
Activity	Immobilized Mouse&Human Chimeric ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His-Avi Tag with the EC50 of 36.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Mouse&Human Chimeric ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His-Avi Tag with the EC50 of 36.8ng/ml determined by ELISA (QC Test).
	Immobilized Human&Mouse Chimeric ITGAV&ITGB6, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human LAP (TGF beta 1), His Tag with the EC50 of 78.4ng/ml determined by ELISA.
	Immobilized Mouse&Human Chimeric ITGAV&ITGB6, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGB6 Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA.
	Mouse&Human Chimeric ITGAV&ITGB6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Mouse&Human Chimeric ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.