• Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Biotinylated Human ITGA4&ITGB7, His-Avi Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA.
  • Amino Acid Range: Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail
Catalog #ITG-HM447B
Price
Regular price $660.00
Regular price Sale price $660.00
/
Size
Avantor VWR Fisher Scientific

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Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447B) Summary

Product Description

 Recombinant Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGA4.It contains Tyr34-Thr977(ITGA4) acidic tail and Glu20-His723(ITGB7) basic tail.

Product Background

 Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.

Product Category

 Recombinant Protein / Antibody discovery / Antibody discovery/Others

Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447B) Specifications/Details

Protein
 Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer
Synonyms
 Integrin alpha 4 beta 7; beta7; alpha 4; LPAM; ITGA4&ITGB7;Integrin alpha 4 β 7; β7
Accession
Species
 Human
Biotinylated
 yes
Amino Acid Range
 Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail
Molecular Weight
 The protein has a predicted MW of 112.5 kDa (ITGA4) and 81.3 kDa (ITGB7). Due to glycosylation, the protein migrates to 68-72 kDa, 78-83 kDa, 110-120 kDa and 130-150 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Biotinylated Human ITGA4&ITGB7, His-Avi Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA.
Product Tag
 C-His-Avi

Fluorophore

 Biotin-labeled
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS, 8% trehalose (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Biotinylated Human ITGA4&ITGB7, His-Avi Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA. Immobilized Biotinylated Human ITGA4&ITGB7, His-Avi Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA.
Immobilized Biotinylated Human ITGA4&ITGB7, His Avi Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human MADCAM1, hFc Tag (Cat. MCM-HM201) with the EC50 of 2.9ng/ml determined by ELISA. Immobilized Biotinylated Human ITGA4&ITGB7, His Avi Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human MADCAM1, hFc Tag (Cat. MCM-HM201) with the EC50 of 2.9ng/ml determined by ELISA.
Biotinylated Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Biotinylated Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Other Available Proteins:
Finding available proteins...
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