Name: Human MUC18/CD146 Protein (MUC-HM118)
Brand: KactusBio
SKU: MUC-HM118-100UG
Price: 330.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA (QC Test).
Amino Acid Range: Val24-Gly559

Catalog #MUC-HM118

Size

100UG

500UG

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Human MUC18/CD146 Protein (MUC-HM118) Summary

Product Description	Recombinant Human MUC18/CD146 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val24-Gly559.
Product Background	METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Human MUC18/CD146 Protein (MUC-HM118) Specifications/Details

Protein	MUC18/CD146
Synonyms	Gicerin; CD146; MCAM; MUC18
Accession	P43121
Species	Human
Biotinylated	no
Amino Acid Range	Val24-Gly559
Molecular Weight	The protein has a predicted MW of 60.8 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA (QC Test).
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 24 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA (QC Test).
	Human MUC18 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human MUC18 is greater than 95% as determined by SEC-HPLC.

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