Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) (IL8-CM1BPB)
Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) (IL8-CM1BPB)
Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) (IL8-CM1BPB)
Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) (IL8-CM1BPB)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
  • Activity: The affinity constant of 1.67 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Thr28-Pro207
Catalog #IL8-CM1BPB
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Product Description
 Recombinant Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the C-Terminus.It contains Thr28-Pro207.
Product Background
 Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Product Category
 Recombinant Protein
Target
 IL-18BP
Accession
Species
 Cynomolgus
Biotinylated
 yes
Amino Acid Range
 Thr28-Pro207
Molecular Weight
 The protein has a predicted MW of 21.14 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 1.67 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Cynomolgus IL-18BP, His tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 1.67 nM as determined in SPR assay (Biacore T200).
Biotinylated Cynomolgus IL-18BP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Cynomolgus IL-18BP is greater than 90% as determined by SEC-HPLC.

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