Product Description |
Recombinant Human CD20 Protein-VLP is expressed from HEK293.It contains Met1-Pro297. |
Product Background |
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. |
Product Category |
Recombinant Protein |
Target |
CD20 |
Synonyms |
MS4A1; CD20; MS4A-1; B1; Bp35; CD20 receptor; CD20S7; CVID5; LEU-16; Ly-44; MS4A2; S7 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Pro297 |
Molecular Weight |
The target protein has a predicted MW of 34.3 kDa. |
Activity |
Immobilized Human CD20 VLP at 5ug/ml (100ul/Well) on plate on the plate. Dose response curve for Ofatumumab, hFc Tag with the EC50 of 10.5ng/ml determined by ELISA (QC Test). See testing image for detail. |
Express System |
HEK293 |
Purity |
> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human CD20 VLP at 5ug/ml (100ul/Well) on plate on the plate. Dose response curve for Ofatumumab, hFc Tag with the EC50 of 10.5ng/ml determined by ELISA (QC Test). |
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Immobilized Human CD20 VLP at 5ug/ml (100ul/Well) on plate on the plate. Dose response curve for Rituximab, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA (QC Test). |
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Immobilized Human CD20 VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Obinutuzumab, hFc Tag with the EC50 of 1.7ng/ml determined by ELISA. |
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The purity of Human CD20 VLP is greater than 95% as determined by SEC-HPLC. |
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