Product Description |
Recombinant Human Claudin 4 Protein-VLP is expressed from HEK293.It contains Met1-Val209. |
Product Background |
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors. |
Product Category |
Recombinant Protein |
Target |
Claudin 4 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Val209 |
Molecular Weight |
The target protein has a predicted MW of 23.31 kDa. |
Activity |
Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. See testing image for detail. |
Express System |
HEK293 |
Purity |
> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. |
|
|
The purity of Human Claudin 4 VLP is greater than 95% as determined by SEC-HPLC. |
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