Human Claudin 4 Protein-VLP (CLD-HM104)
  • Applications: ELISA, SPR, BLI, Yeast Display, Immunization. For other applications, please contact us at support@kactusbio.us. We recommend using Biotinylated VLP for SPR due to easier operation.
  • Express System: HEK293
  • Purity: > 95% as determined by HPLC
  • Activity: Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Met1-Val209
Catalog #CLD-HM104
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Product Description
 Recombinant Human Claudin 4 Protein-VLP is expressed from HEK293.It contains Met1-Val209.
Product Background
 Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
Product Category
 Recombinant Protein
Target
 Claudin 4
Accession
Applications
 ELISA, SPR, BLI, Yeast Display, Immunization. For other applications, please contact us at support@kactusbio.us. We recommend using Biotinylated VLP for SPR due to easier operation.
Species
 Human
Biotinylated
 no
Amino Acid Range
 Met1-Val209
Molecular Weight
 The target protein has a predicted MW of 23.31 kDa.
Activity
 Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. See testing image for detail.
Express System
 HEK293
Purity
 > 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA.
The purity of Human Claudin 4 VLP is greater than 95% as determined by SEC-HPLC.
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