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Cynomolgus CDH17/Cadherin 17 Protein, Ultra Low Endotoxin (CDH-CM127-UL) Summary
Product Description |
Recombinant Cynomolgus CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag at the C-terminus.; It contains Gln23-Thr784. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Cynomolgus CDH17/Cadherin 17 Protein, Ultra Low Endotoxin (CDH-CM127-UL) Specifications/Details
Protein |
CDH17/Cadherin 17 |
Synonyms |
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Gln23-Thr784 |
Molecular Weight |
The protein has a predicted MW of 85.57 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus CDH17, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.2 ng/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Cynomolgus CDH17, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.2 ng/ml determined by ELISA (QC Test). |
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Cynomolgus CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%. |
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Loaded Anti-CDH17 Ab., hFc-Avi Tag on ProA-Biosensor can bind Cynomolgus CDH17, His Tag with an affinity constant of 9.78 nM as determined in BLI assay . |
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The purity of Cynomolgus CDH17 is greater than 90% as determined by SEC-HPLC. |
Other Available Proteins:
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