Name: Cynomolgus Fc gamma RIII/CD16 Protein (FGR-CM1R3)
Brand: KactusBio
SKU: FGR-CM1R3-100UG
Price: 240.0 USD
Availability: InStock

Cynomolgus Fc gamma RIII/CD16 Protein (FGR-CM1R3)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.251 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gly17-Gln208

Catalog #FGR-CM1R3

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus Fc gamma RIII/CD16 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly17-Gln208.
Product Background	Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.
Product Category	Recombinant Protein

Target	Fc gamma RIII/CD16
Synonyms	IgG Fc receptor III; Fc-gamma RIII; FcRIII; FCGR3; CD16; CD16A; FCG3; FcgRIII; FCR-10; FCRIIIA; IGFR3; IMD20
Accession	Q8SPW2-1
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Gly17-Gln208
Molecular Weight	The protein has a predicted MW of 23.1 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 0.251 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Rituximab captured on CM5 Chip via Protein A can bind Cynomolgus Fc gamma RIII, His Tag with an affinity constant of 0.251 uM as determined in SPR assay (Biacore T200).
	Cynomolgus Fc gamma RIII on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus Fc gamma RIII is greater than 95% as determined by SEC-HPLC.

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