Product Description |
Recombinant Cynomolgus IL-17F Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg31-Gln163. |
Product Background |
The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N‑terminus.IL-17F is ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
IL-17F |
Synonyms |
Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Arg31-Gln163 |
Molecular Weight |
The protein has a predicted MW of 16.1 kDa. Due to glycosylation, the protein migrates to 23-28 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.13 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Human IL-17R alpha, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-17F, His Tag with an affinity constant of 0.13 uM as determined in SPR assay (Biacore T200). |
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Cynomolgus IL-17F on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Cynomolgus IL-17F is greater than 95% as determined by SEC-HPLC. |
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