Cynomolgus VSIG4 Protein (VSG-CM104)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Arg25-Ala288

Catalog: VSG-CM104

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Product Description Recombinant Cynomolgus VSIG4 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg25-Ala288.

Product Background

 VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.T cell activation by APCs is positively and negatively regulated by members of the B7 family. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.

Product Category

 Recombinant Protein

Target

 VSIG4

Gene/Protein ID

 A0A7N9D9P6

Species

 Cynomolgus

Exact Sequence

 Arg25-Ala288
Molecular Weight The protein has a predicted MW of 30.16 kDa. Due to glycosylation, the protein migrates to 35-50 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Cynomolgus VSIG4 is greater than 95% as determined by SEC-HPLC.
Cynomolgus VSIG4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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