Name: Human FGFR3 alpha (IIIb) Protein (FGF-HM43B)
Brand: KactusBio
SKU: FGF-HM43B-100UG
Price: 247.5 USD
Availability: InStock

Human FGFR3 alpha (IIIb) Protein (FGF-HM43B)

Immobilized Human FGFR3 alpha (IIIb) , His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.

Human FGFR3 alpha (IIIb) on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

The purity of Human FGFR3 alpha (IIIb) is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human FGFR3 alpha (IIIb) , His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Glu23-Gly377

Catalog #FGF-HM43B

Size

100UG

500UG

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Product Description	Recombinant Human FGFR3 (IIIb) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Glu23-Gly377.
Product Background	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Product Category	Recombinant Protein / Antibody discovery

Protein	FGFR3 alpha (IIIb)
Synonyms	ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
Accession	P22607-2
Species	Human
Biotinylated	no
Amino Acid Range	Glu23-Gly377
Molecular Weight	The protein has a predicted MW of 41.4 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human FGFR3 alpha (IIIb) , His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human FGFR3 alpha (IIIb) , His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.
	Human FGFR3 alpha (IIIb) on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
	The purity of Human FGFR3 alpha (IIIb) is greater than 95% as determined by SEC-HPLC.