Human GITR Ligand/TNFSF18 Trimer Protein (FSF-HM418)
Human GITR Ligand/TNFSF18 Trimer Protein (FSF-HM418)
Human GITR Ligand/TNFSF18 Trimer Protein (FSF-HM418)
Human GITR Ligand/TNFSF18 Trimer Protein (FSF-HM418)
  • Express System: HEK293
  • Product Tag: N-His-Flag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human GITR Ligand Trimer, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GITR, hFc Tag with the EC50 of 50.8ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Gln50-Ser177
Catalog #FSF-HM418
Regular price $270.00
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Product Description
Recombinant Human GITR Ligand/TNFSF18 Trimer Protein is expressed from HEK293 with His tag and flag tag at the N-Terminus.It contains Gln50-Ser177.
Product Background
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept.
Product Category
Recombinant Protein
Target
GITR Ligand/TNFSF18 Trimer
Synonyms
TNFSF18; AITRL; TL6; GITRL; GITR Ligand
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Gln50-Ser177
Molecular Weight
The protein has a predicted MW of 47.5 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human GITR Ligand Trimer, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GITR, hFc Tag with the EC50 of 50.8ng/ml determined by ELISA. See testing image for detail.
Product Tag
N-His-Flag
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human GITR Ligand Trimer, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human GITR, hFc Tag with the EC50 of 50.8ng/ml determined by ELISA.
Human GITR Ligand Trimer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human GITR Ligand Trimer is greater than 95% as determined by SEC-HPLC.

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