Name: Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein (MHC-HE450)
Brand: KactusBio
SKU: MHC-HE450-100UG
Price: 341.0 USD
Availability: InStock

Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein (MHC-HE450)

Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer is greater than 95% as determined by SEC-HPLC.

Express System: E.coli
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLAVEEVSL peptide

Catalog #MHC-HE450

Size

100UG

500UG

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Product Description	Recombinant Human HLA-A02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus.It contains Gly25-Thr305(HLA-A02:01), Ile21-Met119(B2M) and CLAVEEVSL peptide.
Product Background	The nucleophosmin (NPM1) mutant protein, a-leukemia-associated antigen-characterized by its leukemia-restricted expression and immunogenic potential, has emerged as a promising therapeutic target for acute myeloid leukemia (AML) immunotherapy. Among its immunogenic epitopes, the-CLAVEEVSL peptide-derived from the full C-terminal region of the NPM1-mutated isoform demonstrates potent immunogenicity, making it a prime candidate for T cell-based immunotherapies.
Product Category	Recombinant Protein / Antibody discovery / MHCPeptide-MHCs

Protein	HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL)
Synonyms	NPM1-CLAV (CLAVEEVSL); NPM1-CLAV; CLAVEEVSL;
MHC Form	Monomer
Allele	HLA-A*02:01
Accession	A0A140T913(HLA-A*02:01)&P61769(B2M)&CLAVEEVSL
Species	Human
Biotinylated	no
Amino Acid Range	Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLAVEEVSL peptide
Molecular Weight	The protein has a predicted MW of 35.6 kDa (HLA-A*02:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
Product Tag	C-His-Avi
Expression System	E.coli
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in 20mM Tris, 200mM NaCl (pH 8.0).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer is greater than 95% as determined by SEC-HPLC.