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Human IL-22R alpha 1 Protein, Ultra Low Endotoxin (ILR-HM122-UL) Summary
Product Description |
Recombinant Human IL-22R alpha 1 Protein is expressed from HEK293 with His tag at the C-terminus.It contains His16-Thr228. |
Product Background |
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human IL-22R alpha 1 Protein, Ultra Low Endotoxin (ILR-HM122-UL) Specifications/Details
Protein |
IL-22R alpha 1 |
Synonyms |
IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11; IL22 R; IL-22 R |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
His16-Thr228 |
Molecular Weight |
The protein has a predicted MW of 25.67 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human IL-22R alpha 1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-22R alpha 1 Antibody, hFc Tag with the EC50 of 6.4ng/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.； -80°C for 3 months after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human IL-22R alpha 1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-22R alpha 1 Antibody, hFc Tag with the EC50 of 6.4ng/ml determined by ELISA (QC Test). |
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Human IL-22R alpha 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human IL-22R alpha 1 is greater than 95% as determined by SEC-HPLC. |
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