Product Description |
Recombinant Human KIR2DL2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His22-His245. |
Product Background |
KIR2DL2 (2DL2, formerly NKAT6, designated CD158b) is a 348 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig‑like receptor (KIR) family. KIRs are expressed on human CD56dim NK cells and T cell subsets, and regulate effector functions in the innate immune system.KIR2DL2 is receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
KIR2DL2 |
Synonyms |
NKAT-6;p58 NK receptor CL-43;CD158b1;KIR2DL2;CD158B1;NKAT6 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
His22-His245 |
Molecular Weight |
The protein has a predicted MW of 27.4 kDa. Due to glycosylation, the protein migrates to 45-50 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human KIR2DL2 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. |
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The purity of Human KIR2DL2 is greater than 95% as determined by SEC-HPLC. |
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