Name: Human KLRG1 Protein (KLR-HM2G1)
Brand: KactusBio
SKU: KLR-HM2G1-100UG
Price: 330.0 USD
Availability: InStock

Express System: HEK293
Product Tag: N-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human KLRG1, hFc Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-KLRG1 Antibody, hFc Tag with the EC50 of 24.9ng/ml determined by ELISA.
Amino Acid Range: Leu60-Phe195

Catalog #KLR-HM2G1

Size

100UG

500UG

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Human KLRG1 Protein (KLR-HM2G1) Summary

Product Description	Recombinant Human KLRG1 Protein is expressed from HEK293 with hFc (IgG1) tag at the N-Terminus.It contains Leu60-Phe195.
Product Background	Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3 effector phenotype.Lack of KLRG1 on Treg cells conferred on them a competitive advantage in the gut, but not in lymphoid organs. Hence, although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human KLRG1 Protein (KLR-HM2G1) Specifications/Details

Protein	KLRG1
Synonyms	KLRG1; CLEC15A; MAFA; MAFAL; 2F1; CLEC15AMAFA-LIKE; MGC13600
Accession	Q96E93-1
Species	Human
Biotinylated	no
Amino Acid Range	Leu60-Phe195
Molecular Weight	The protein has a predicted MW of 42.8 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human KLRG1, hFc Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-KLRG1 Antibody, hFc Tag with the EC50 of 24.9ng/ml determined by ELISA.
Product Tag	N-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 24 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human KLRG1, hFc Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-KLRG1 Antibody, hFc Tag with the EC50 of 24.9ng/ml determined by ELISA.
	Human KLRG1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human KLRG1 is greater than 95% as determined by SEC-HPLC.

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