Human SIGIRR Protein (SGR-HM201)
Human SIGIRR Protein (SGR-HM201)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Met1-His118
Catalog #SGR-HM201
Regular price $240.00
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Product Description
Recombinant Human SIGIRR Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Met1-His118.
Product Background
TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1.
Product Category
Recombinant Protein
Target
SIGIRR
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Met1-His118
Molecular Weight
The protein has a predicted MW of 39.29 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Product Tag
C-hFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human SIGIRR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human SIGIRR is greater than 95% as determined by SEC-HPLC.

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