Product Description |
Recombinant Human SIGIRR Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Met1-His118. |
Product Background |
TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
SIGIRR |
Synonyms |
TIR8; Single Ig IL-1-related receptor; IL-1R8 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-His118 |
Molecular Weight |
The protein has a predicted MW of 39.29 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human SIGIRR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human SIGIRR is greater than 95% as determined by SEC-HPLC. |
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