• Description: IdeS (Immunoglobulin G-degrading enzyme of Streptococcus pyogenes), also known as Mac-1， is a type of Cysteine protease secreted by Streptococcus pyogenes. IdeS has very high substrate specificity and can only recognize IgG (no IgA, IgD, IgE, or IgM) and digest specific locus under the hinge region, hydrolyzing IgG into F(ab’)2 and Fc fragments. IdeS can recognize IgG molecules from human or other animal resources such as sheep, rabbits, monkeys, or even chimeric IgG. It also exhibits certain reactivity to mouse IgG2a and IgG3 IdeS cab also catalyze Fc fusion protein and ADC (antibody-drug conjugate) hydrolysis.
  • Applications: Hydrolysis of therapeutic antibody (IgG), Fc fusion protein, Antibody-Drug Conjugates.
  • Express System: E.coli
Catalog #IDE-SE101
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Product Description
 IdeS (Immunoglobulin G-degrading enzyme of Streptococcus pyogenes), also known as Mac-1， is a type of Cysteine protease secreted by Streptococcus pyogenes. IdeS has very high substrate specificity and can only recognize IgG (no IgA, IgD, IgE, or IgM) and digest specific locus under the hinge region, hydrolyzing IgG into F(ab’)2 and Fc fragments. IdeS can recognize IgG molecules from human or other animal resources such as sheep, rabbits, monkeys, or even chimeric IgG. It also exhibits certain reactivity to mouse IgG2a and IgG3 IdeS cab also catalyze Fc fusion protein and ADC (antibody-drug conjugate) hydrolysis.
Product Background
 IdeS (Immunoglobulin G-degrading enzyme of Streptococcus pyogenes), also known as Mac-1， is a type of Cysteine protease secreted by Streptococcus pyogenes.
Applications
 Hydrolysis of therapeutic antibody (IgG), Fc fusion protein, Antibody-Drug Conjugates.
Concentration
 50 U/μl
Unit Definition
 One unit (1U) is defined as the amount of enzymes required to digest >95% of 1ug recombinant monoclonal IgG at 37℃ for 30 min.
Source
 E.coli
Biotinylated
 no
Express System
 E.coli
Shipping
 Shipping with dry ice.
Stability And Storage
 Store at -20±5℃. Avoid repeated freeze-thaw cycles.

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