MaxNuclease, GMP Grade (GMP-NUC-SE101)
Catalog: GMP-NUC-SE101
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| Product Description | DMF filed- this product has been submitted to FDA's Drug Master Files (DMFs) and is granted the DMF #036799. MaxNuclease is a non-specific nucleic acid endonuclease derived from Serratia Marcescens that degrades both DNA and RNA such as double-stranded, single-stranded, linear, circular or supercoiled. No base preference is observed. MaxNuclease hydrolyzes internal phosphodiester bonds between the nucleotides and completely digests nucleic acids into two to five bases in length. Expressed in E.Coli that carries the nuclease gene from Serratia Marcescens. |
| Product Category | GMP Enzyme |
| Application | Removing all forms of DNA and RNA from biological products Reducing viscosity caused by nucleic acids Purification of viral vaccines, viral vectors for vaccine |
| Concentration | 250U/UL |
| Unit Definition | One unit is defined as the amount of enzyme required to produce a change in absorbance at 260 nm of 1.0 in the time of 30 min, under optimum conditions with the excess substrate. |
| Molecular Weight | 27.8 kD |
| Express System | E.coli |
| Quality Statement | Manufactured to the GMP guidelines Accepted by the FDA's Drug Master Files (DMF) database, DMF#036799 |
| QC Standard | Activity: >=250 U/UL
Purity: >=95%(Tris-Bis PAGE)>=99%(SEC-HPLC) Residual Protease: Negative Endotoxin: <=0.01 EU/kU Residual Host Protein: <=10 ppm Sterility: Negative Mycoplasma: Negative |
| Form | Liquid |
| Shipping | Shipped with blue ice |
| Stability And Storage | -20°C for 12 months. Avoid repeated freeze-thaw cycles. |
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Tris-Bis-PAGE shows purity >95% |
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SEC-HPLC shows purity >99% |
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Benchmark testing against a leading competitor's similar product. |
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