Mouse Clusterin Protein (CLN-MM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Glu22-Glu448

Catalog: CLN-MM101

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Product Description Recombinant Mouse Clusterin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu22-Glu448.

Product Background

Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU.

Product Category

Recombinant Protein

Target

Clusterin
Synonyms Clusterin; Apolipoprotein J; Apo-J; Clustrin; SGP-2; Msgp-2; CLU; AAG4; APOJ; CLI; KUB1; SP-40; TRPM2; CLI; CLU1; CLU2; KUB1; NA1/NA2; KUB1SGP2; MGC24903
Accession

Species

Mouse

Amino Acid Range

Glu22-Glu448
Molecular Weight The protein has a predicted MW of 50.4 kDa. Due to autocatalytic cleavage, the protein migrates to 35-40 kDa and 43-50 kDa based on Tris-Bis PAGE result.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse Clusterin is greater than 95% as determined by SEC-HPLC.
Mouse Clusterin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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