Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (ITG-MM12B)
Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (ITG-MM12B)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
  • Amino Acid Range: Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail
Catalog #ITG-MM12B
Regular price $375.00
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Product Description
Recombinant Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg988 (ITGA2B) acidic tail and Glu26-Asp717 (ITGB3) basic tail.
Product Background
Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.
Product Category
Recombinant Protein
Target
Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer
Synonyms
ITGA2B&ITGB3; ITGA2B; ITGB3
Accession
Species
Mouse
Biotinylated
no
Amino Acid Range
Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail
Molecular Weight
The protein has a predicted MW of 109.80 kDa (ITGA2B) and 80.80 kDa (ITGB3). Due to glycosylation, the protein migrates to 90-113 kDa based on Bis-Tris PAGE result.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse ITGA2B&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse ITGA2B&ITGB3 is greater than 90% as determined by SEC-HPLC.

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