Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (ITG-MM12B)
Catalog: ITG-MM12B
Order now get it on
| Product Description | Recombinant Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail. |
Product Background |
Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer |
| Synonyms | ITGA2B&ITGB3; ITGA2B; ITGB3 |
Gene/Protein ID |
Q9QUM0(ITGA2B)&O54890(ITGB3) |
Species |
Mouse |
Exact Sequence |
Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail |
| Molecular Weight | The protein has a predicted MW of 109.80 kDa (ITGA2B)&80.80 kDa (ITGB3). Due to glycosylation, the protein migrates to 90-113 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
The purity of Mouse ITGA2B&ITGB3 is greater than 95% as determined by SEC-HPLC. |
|
|
Mouse ITGA2B&ITGB3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
You may also be interested in
View more associated products