Product Description |
Recombinant Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg988 (ITGA2B) acidic tail and Glu26-Asp717 (ITGB3) basic tail. |
Product Background |
Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer |
Synonyms |
α2Bβ3; ITGA2B&ITGB3; ITGA2B; ITGB3 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail |
Molecular Weight |
The protein has a predicted MW of 109.80 kDa (ITGA2B) and 80.80 kDa (ITGB3). Due to glycosylation, the protein migrates to 90-113 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Mouse ITGA2B&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Mouse ITGA2B&ITGB3 is greater than 90% as determined by SEC-HPLC. |
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