Rhesus macaque IL-18 R1/CD218a Protein (IL8-RM2R1)
Catalog: IL8-RM2R1
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| Product Description | Recombinant Rhesus macaque IL-18 R1/CD218a Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Cys22-Gly329. |
Product Background |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. |
Product Category |
Recombinant Protein |
Target |
IL-18 R1/CD218a |
| Accession | |
Species |
Rhesus macaque |
Amino Acid Range |
Cys22-Gly329 |
| Molecular Weight | The protein has a predicted MW of 61.96 kDa. Due to glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Rhesus macaque IL-18 R1, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 0.42ug/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Rhesus macaque IL-18 R1, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 0.42ug/ml determined by ELISA. |
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The purity of Rhesus macaque IL-18 R1 is greater than 95% as determined by SEC-HPLC. |
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Rhesus macaque IL-18 R1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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