Product Description |
Recombinant Rhesus macaque Siglec-2/CD22 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser20-Arg686. |
Product Background |
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. |
Product Category |
Recombinant Protein |
Target |
Siglec-2/CD22 |
Accession |
|
Species |
Rhesus macaque |
Biotinylated |
no |
Amino Acid Range |
Ser20-Arg686 |
Molecular Weight |
The protein has a predicted MW of 76.14 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.92 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Anti-Siglec-2 Antibody captured on CM5 Chip via Protein A can bind Rhesus macaque siglec-2, His Tag with an affinity constant of 0.92 uM as determined in SPR assay (Biacore T200). |
|
|
Rhesus macaque Siglec-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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