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Rhesus macaque Siglec-2/CD22 Protein (SIG-CM122) Summary
Product Description |
Recombinant Rhesus macaque Siglec-2/CD22 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser20-Arg686. |
Product Background |
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. |
Product Category |
Recombinant Protein / Antibody discovery / CAR-T targets | ADC targets |
Rhesus macaque Siglec-2/CD22 Protein (SIG-CM122) Specifications/Details
Protein |
Siglec-2/CD22 |
Synonyms |
CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814 |
Accession |
|
Species |
Rhesus macaque |
Biotinylated |
no |
Amino Acid Range |
Ser20-Arg686 |
Molecular Weight |
The protein has a predicted MW of 76.14 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.92 uM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Anti-Siglec-2 Antibody captured on CM5 Chip via Protein A can bind Rhesus macaque siglec-2, His Tag with an affinity constant of 0.92 uM as determined in SPR assay (Biacore T200). |
|
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Rhesus macaque Siglec-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
Other Available Proteins:
Finding available proteins...
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