C-C Motif Chemokine Receptor 2: CCR2b


The chemokine receptor CCR2B, one of two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), plays a pivotal role in attracting monocytes and is implicated in various chronic inflammatory conditions. An actin-binding protein known as filamin A (FLNa) interacts with the carboxyl-terminal tail of CCR2B. FLNa assumes a significant role in regulating the internalization and precise spatial distribution of the CCR2B receptor within dynamic membrane structures.



Available Products

Performance Validation



Immobilized Human CCR2b VLP at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CCR2b Antibody, hFc Tag with the EC50 of 12.0ng/ml determined by ELISA.

Biotinylated Human CCR2b VLP captured on SA Chip can bind Anti-CCR2b Antibody with an affinity constant of 5.24 nM as determined in SPR assay (Biacore T200).

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Quality Control

KACTUS products are validated for purity and bioactivity using analytical techniques such as Bis-Tris, HPLC, ELISA, and SPR. Our proteins are designed and manufactured in-house using our SAMS protein engineering platform and high-standard manufacturing facilities.

Process Validation

We monitor the entire production process to ensure expression conditions are optimal for that specific protein. This includes monitoring (1) growth of host cells, (2) expression of the target gene, and (3) purification of the recombinant protein. Moreover, we've optimized the expression process to minimize the presence of contaminants that can affect the purity or activity of the final product.

Analytical Testing

PURITY KACTUS ensures the purity of each recombinant protein using HPLC and Bis-Tris Page. Additionally, we quantify the level of impurities, such as host cell proteins, endotoxin, and host cell DNA in the final product. 

ACTIVITY We analyze the potency of our recombinant proteins by measuring in vitro activity, such as its ability to bind to its target molecule via ELISA or SPR assay. 

CONSISTENCY Our team tests for batch-to-batch consistency to ensure stable bioactivity across lots. Additionally, we assess stability of our proteins by measuring degradation over time and resistance to environmental stress factors, such as temperature and pH changes.

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