Claudin 18.2


Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.


CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ

Available Products

Performance Validation


Human Claudin 18.2 VLP immobilized on CM5 Chip can bind Anti-Claudin18.2 Antibody with an affinity constant of 2.20 nM as determined in SPR assay (Biacore T200).

Biotinylated Human Claudin18.2 VLP captured on CM5 Chip via Streptavidin can bind Anti-Claudin18.2 Antibody with an affinity constant of 1.28 nM as determined in SPR assay (Biacore T200) (QC Test).

Immobilized Human Claudin 18.2 VLP at 5ug/ml (100ul/Well). Dose response curve for Anti-Claudin 18.2 Antibody, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA (QC Test).

The purity of Human Claudin 18.2 VLP is greater than 95% as determined by SEC-HPLC.

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Quality Control

KACTUS products are validated for purity and bioactivity using analytical techniques such as Bis-Tris, HPLC, ELISA, and SPR. Our proteins are designed and manufactured in-house using our SAMS protein engineering platform and high-standard manufacturing facilities.

Process Validation

We monitor the entire production process to ensure expression conditions are optimal for that specific protein. This includes monitoring (1) growth of host cells, (2) expression of the target gene, and (3) purification of the recombinant protein. Moreover, we've optimized the expression process to minimize the presence of contaminants that can affect the purity or activity of the final product.

Analytical Testing

PURITY KACTUS ensures the purity of each recombinant protein using HPLC and Bis-Tris Page. Additionally, we quantify the level of impurities, such as host cell proteins, endotoxin, and host cell DNA in the final product. 

ACTIVITY We analyze the potency of our recombinant proteins by measuring in vitro activity, such as its ability to bind to its target molecule via ELISA or SPR assay. 

CONSISTENCY Our team tests for batch-to-batch consistency to ensure stable bioactivity across lots. Additionally, we assess stability of our proteins by measuring degradation over time and resistance to environmental stress factors, such as temperature and pH changes.

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