Claudin 18.2

Performance Validation

 

Human Claudin 18.2 VLP immobilized on CM5 Chip can bind Anti-Claudin18.2 Antibody with an affinity constant of 2.20 nM as determined in SPR assay (Biacore T200).

Biotinylated Human Claudin18.2 VLP captured on CM5 Chip via Streptavidin can bind Anti-Claudin18.2 Antibody with an affinity constant of 1.28 nM as determined in SPR assay (Biacore T200) (QC Test).

Immobilized Human Claudin 18.2 VLP at 5ug/ml (100ul/Well). Dose response curve for Anti-Claudin 18.2 Antibody, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA (QC Test).

The purity of Human Claudin 18.2 VLP is greater than 95% as determined by SEC-HPLC.