Product Description |
Recombinant Biotinylated Human/Cynomolgus Activin RIIB/ACVR2B Protein (Primary Amine Labeling) is expressed from HEK293 with mFc (IgG1) tag at the C-terminus.It contains Ser19-Thr137 (Human) / Ser40-Thr158 (Cynomolgus). |
Product Background |
ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myostatin (MSTN), growth differentiation factor 11 (GDF11), and bone morphogenetic protein 9 (BMP9). |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
Activin RIIB/ACVR2B |
Synonyms |
Activin receptor type-2B; ACVR2B; Activin RIIB |
Accession |
|
Species |
Human/Cynomolgus |
Biotinylated |
yes |
Amino Acid Range |
Ser19-Thr137 (Human) / Ser40-Thr158 (Cynomolgus) |
Molecular Weight |
The protein has a predicted MW of 39.32 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human Activin A, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human/Cynomolgus Activin RIIB, mFc Tag with the EC50 of 50.5ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-mFc |
Expression System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human Activin A, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human/Cynomolgus Activin RIIB, mFc Tag with the EC50 of 50.5ng/ml determined by ELISA (QC Test). |
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Biotinylated Human/Cynomolgus Activin RIIB on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Human/Cynomolgus Activin RIIB is greater than 95% as determined by SEC-HPLC. |
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