Biotinylated Human/Cynomolgus Activin RIIB/ACVR2B Protein (Primary Amine Labeling) (ARB-HM32BB)
  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: Immobilized Human Activin A, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human/Cynomolgus Activin RIIB, mFc Tag with the EC50 of 50.5ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Ser19-Thr137 (Human) / Ser40-Thr158 (Cynomolgus)
Catalog #ARB-HM32BB
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Product Description
 Recombinant Biotinylated Human/Cynomolgus Activin RIIB/ACVR2B Protein (Primary Amine Labeling) is expressed from HEK293 with mFc (IgG1) tag at the C-terminus.It contains Ser19-Thr137 (Human) / Ser40-Thr158 (Cynomolgus).
Product Background
 ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myostatin (MSTN), growth differentiation factor 11 (GDF11), and bone morphogenetic protein 9 (BMP9).
Product Category
 Recombinant Protein
Target
 Activin RIIB/ACVR2B
Synonyms
 Activin receptor type-2B; ACVR2B; Activin RIIB
Accession
Species
 Human/Cynomolgus
Biotinylated
 yes
Amino Acid Range
 Ser19-Thr137 (Human) / Ser40-Thr158 (Cynomolgus)
Molecular Weight
 The protein has a predicted MW of 39.32 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human Activin A, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human/Cynomolgus Activin RIIB, mFc Tag with the EC50 of 50.5ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 C-mFc
Express System
 HEK293
Purity
 >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human Activin A, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human/Cynomolgus Activin RIIB, mFc Tag with the EC50 of 50.5ng/ml determined by ELISA (QC Test).
Biotinylated Human/Cynomolgus Activin RIIB on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human/Cynomolgus Activin RIIB is greater than 95% as determined by SEC-HPLC.

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