Name: Human GDF15 (H202D) Protein (GDF-HM216)
Brand: KactusBio
SKU: GDF-HM216-100UG
Price: 375.0 USD
Availability: InStock

Express System: HEK293
Product Tag: N-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human GFRAL, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human GDF15 (H202D), hFc Tag with the EC50 of 4.1ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Ala197-Ile308 (H202D)

Catalog #GDF-HM216

Size

100UG

500UG

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Product Description	Recombinant Human GDF15 (H202D) Protein is expressed from HEK293 with hFc tag at the N-terminus.It contains Ala197-Ile308 (H202D).
Product Background	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
Product Category	Recombinant Protein / Antibody discovery

Protein	GDF15 (H202D)
Synonyms	GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β
Accession	Q99988
Species	Human
Biotinylated	no
Amino Acid Range	Ala197-Ile308 (H202D)
Molecular Weight	The protein has a predicted MW of 37.88 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human GFRAL, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human GDF15 (H202D), hFc Tag with the EC50 of 4.1ng/ml determined by ELISA. See testing image for detail.
Product Tag	N-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human GFRAL, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human GDF15 (H202D), hFc Tag with the EC50 of 4.1ng/ml determined by ELISA.
	Human GDF15 (H202D) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human GDF15 (H202D) is greater than 95% as determined by SEC-HPLC.