Human CA14/Carbonic Anhydrase XIV Protein (CA4-HM214)
  • Express System: HEK293
  • Product Tag: C-hFc (IgG1)
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Measured by its esterase activity. The specific activity is >100 pmol/min/µg.
  • Amino Acid Range: Ala16-Met290
  • Other Available Proteins:
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Catalog #CA4-HM214
Regular price $345.00
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Size
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Human CA14/Carbonic Anhydrase XIV Protein (CA4-HM214) Summary

Product Description

Recombinant Human CA14/Carbonic Anhydrase XIV Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Ala16-Met290.

Product Background

Carbonic anhydrase XIV (CA XIV), a transmembrane protein, highly expressed in the central nervous system, is difficult to recombinantly express and purify in large scale for the measurements of inhibitor binding and drug design. CA XIV belongs to the family of twelve catalytically active CA isoforms in the human body. Disorders in the expression of CA XIV cause serious diseases and CA XIV has been described as a possible drug target for the treatment of epilepsy, some retinopathies, and skin tumors.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Human CA14/Carbonic Anhydrase XIV Protein (CA4-HM214) Specifications/Details

Protein
CA14/Carbonic Anhydrase XIV
Synonyms
Carbonic anhydrase 14; EC:4.2.1.1; CA-XIV
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Ala16-Met290
Molecular Weight
The protein has a predicted MW of 56.76 kDa. Due to glycosylation, the protein migrates to 65-85 kDa based on Bis-Tris PAGE result.
Activity
Measured by its esterase activity. The specific activity is >100 pmol/min/µg.
Product Tag
C-hFc (IgG1)

Fluorophore

Unconjugated
Expression System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE
Endotoxin
Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
Liquid
Shipping
Shipped with dry ice.
Formulation
Supplied as 0.22 um filtered solution in 20mM Tris, 150mM NaCl (pH 7.5).
Stability And Storage
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human Carbonic Anhydrase XIV on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human Carbonic Anhydrase XIV on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
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