HPLC chromatogram with major peak at 6.772 minutes and minor peaks at 5.912 and 9.085 minutes, showing sample purity and potential impurities.
Human CLEC4M/CD299 Protein (CLE-HM64E)
HPLC chromatogram with major peak at 6.772 minutes and minor peaks at 5.912 and 9.085 minutes, showing sample purity and potential impurities.
Human CLEC4M/CD299 Protein (CLE-HM64E)
  • Express System: HEK293
  • Product Tag: N-His-Flag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gln71-Glu399
  • Other Available Proteins:
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Catalog #CLE-HM64E
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Size
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Human CLEC4M/CD299 Protein (CLE-HM64E) Summary

Product Description

 Recombinant Human CLEC4M/CD299 Protein is expressed from HEK293 with His tag and Flag tag at the N-terminus.It contains Gln71-Glu399.

Product Background

 CLEC4M, also known as DC-SIGNR, L-SIGN or CD209L, is a Ca2+-dependent C-type lectin. CLEC4M and its homologue DC-SIGN are encoded by the closely related lectin gene cluster on chromosome 19p13.3. higher expression of CLEC4M is associated with poor clinical prognosis in lung cancer patients and enhances the resistance of NSCLC cells to cisplatin. Inhibition of CLEC4M expression significantly increased cisplatin sensitivity, suggesting potential clinical significance for targeting CLEC4M in overcoming cisplatin resistance.

Product Category

 Recombinant Protein / Antibody discovery / Antibody discovery | Others

Human CLEC4M/CD299 Protein (CLE-HM64E) Specifications/Details

Protein
 CLEC4M/CD299
Synonyms
 CLEC4M; CD299; DC-SIGNR; DC-SIGN2; L-SIGN; CD209L; CD209L1
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gln71-Glu399
Molecular Weight
 The protein has a predicted MW of 39.81 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Product Tag
 N-His-Flag

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
 -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human CLEC4M on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human CLEC4M on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CLEC4M is greater than 95% as determined by SEC-HPLC. The purity of Human CLEC4M is greater than 95% as determined by SEC-HPLC.
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support@kactusbio.us

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