Product Description |
Recombinant Human CLEC4M/CD299 Protein is expressed from HEK293 with His tag and Flag tag at the N-terminus.It contains Gln71-Glu399. |
Product Background |
CLEC4M, also known as DC-SIGNR, L-SIGN or CD209L, is a Ca2+-dependent C-type lectin. CLEC4M and its homologue DC-SIGN are encoded by the closely related lectin gene cluster on chromosome 19p13.3. higher expression of CLEC4M is associated with poor clinical prognosis in lung cancer patients and enhances the resistance of NSCLC cells to cisplatin. Inhibition of CLEC4M expression significantly increased cisplatin sensitivity, suggesting potential clinical significance for targeting CLEC4M in overcoming cisplatin resistance. |
Product Category |
Recombinant Protein |
Target |
CLEC4M/CD299 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln71-Glu399 |
Molecular Weight |
The protein has a predicted MW of 39.81 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result. |
Product Tag |
N-His-Flag |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human CLEC4M on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human CLEC4M is greater than 95% as determined by SEC-HPLC. |
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