Human CLEC4M/CD299 Protein (CLE-HM64E)

  • Express System: HEK293
  • Product Tag: N-His-Flag
  • Purity: > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
  • Amino Acid Range: Gln71-Glu399

Catalog: CLE-HM64E

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Product Description Recombinant Human CLEC4M/CD299 Protein is expressed from HEK293 with His tag and Flag tag at the N-terminus.It contains Gln71-Glu399.

Product Background

 CLEC4M, also known as DC-SIGNR, L-SIGN or CD209L, is a Ca2+-dependent C-type lectin. CLEC4M and its homologue DC-SIGN are encoded by the closely related lectin gene cluster on chromosome 19p13.3. higher expression of CLEC4M is associated with poor clinical prognosis in lung cancer patients and enhances the resistance of NSCLC cells to cisplatin. Inhibition of CLEC4M expression significantly increased cisplatin sensitivity, suggesting potential clinical significance for targeting CLEC4M in overcoming cisplatin resistance.

Product Category

 Recombinant Protein

Target

 CLEC4M/CD299
Accession

Species

 Human

Amino Acid Range

 Gln71-Glu399
Molecular Weight The protein has a predicted MW of 39.81 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

Product Tag

 N-His-Flag

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human CLEC4M is greater than 95% as determined by SEC-HPLC.
Human CLEC4M on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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