Human TRAIL Trimer Protein (TRL-HM101)
Human TRAIL Trimer Protein (TRL-HM101)
Human TRAIL Trimer Protein (TRL-HM101)
Human TRAIL Trimer Protein (TRL-HM101)
  • Express System: HEK293
  • Product Tag: N-His-Flag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
  • Activity: Immobilized Human TRAIL Trimer, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Gly118-Gly281
Catalog #TRL-HM101
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Product Description
 Recombinant Human TRAIL Trimer Protein is expressed from HEK293 with His tag and Flag tag at the N-Terminus.It contains Gly118-Gly281.
Product Background
 Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
Product Category
 Recombinant Protein
Target
 Trail Trimer
Synonyms
 Apo-2L; TRAIL; CD253; TNFSF10; Apo-2 ligand; APO2L; TL2
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gly118-Gly281
Molecular Weight
 The protein has a predicted MW of 60 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human TRAIL Trimer, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA. See testing image for detail.
Product Tag
 N-His-Flag
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human TRAIL Trimer, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA.
Human TRAIL Trimer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human TRAIL Trimer is greater than 90% as determined by SEC-HPLC.
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