Articles on GPCRS

G-protein coupled receptors (GPCRs) are pivotal targets in drug discovery due to their central role in cellular signaling. This category provides in-depth analysis of GPCR structures, signaling mechanisms, and advances in therapeutic targeting.



Featured Article

MRGPRX2: A Promising Target for Antibody Discovery in Allergy and Pain Disorders

Recent studies have shown that various drugs, including small molecules, opioids, and antibiotics, can activate MRGPRX2 (Mas-related G-protein coupled receptor X2), leading to mast cell degranulation and triggeringdrug hypersensitivity reactions.

Browse articles by topic:

MRGPRX2: A Promising Target for Antibody Discovery in Allergy and Pain Disorders

October 28, 2024

6 min read

GPCRs for Drug Discovery and Development

September 20, 2023

2 min read

The New Frontier in SCLC Treatment: 4 Antigens Driving Antibody Innovation

June 25, 2025

9 min read

STEAP1, the next blockbuster target for Prostate Cancer

June 16, 2025

5 min read

Targeted Therapies for Inflammatory Bowel Disease (IBD)

May 28, 2025

6 min read

The Landscape of GPCR-targeting Antibody Drug Development

May 9, 2025

9 min read

For Better Symptom Relief: Targeted Therapy for Asthma

April 15, 2025

11 min read

At the Crossroads of Metabolic and Cancer Therapeutics — GDF15

April 1, 2025

7 min read

NPR1: Major Drug Target for Heart Failure

February 25, 2025

5 min read

Immunotherapy Target: CD19 Antigen

February 4, 2025

7 min read

Case Review: Exploring domain proteins in antibody development

January 22, 2025

8 min read

GDF-8 (Myostatin) antibody Apitegromab achieves success in Phase III clinical trial

June 13, 2024

4 min read

MSLN Targeted Drugs Entering the Fast Lane

February 29, 2024

5 min read

New target for colorectal cancer: GPA33

February 24, 2023

4 min read

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The Rise of Allogeneic Cell Therapies: Strategies, Challenges, and Clinical Advances

April 8, 2025

7 min read

CDH17: A Safe CAR-T Target for Treatment of Solid Tumors

July 19, 2022

5 min read

MRGPRX2: A Promising Target for Antibody Discovery in Allergy and Pain Disorders

October 28, 2024

6 min read

GPCRs for Drug Discovery and Development

September 20, 2023

2 min read

TM4SF1 in Cancer Immunotherapy: Emerging Research and Clinical Potential

September 5, 2022

5 min read

Beyond GLP-1: ALK7–Activin E as a More Targeted Approach to Obesity Therapy

December 15, 2025

7 min read

GDF-8: A New Era in Muscle Growth Therapies is Coming to Market

December 9, 2025

4 min read

KLK2: The New Promising Target for Prostate Cancer

December 4, 2025

4 min read

CDCP1: A New Therapeutic Target for Malignant Tumors

November 26, 2025

6 min read

IgE:  The Key Therapeutic Target for Allergy Treatment

November 20, 2025

7 min read

CDH17: The Next Breakthrough in Gastrointestinal Cancer Therapy

November 12, 2025

7 min read

FcRh5: An Emerging Therapeutic Target in Multiple Myeloma

October 22, 2025

7 min read

BAFF and APRIL: Key Targets in Autoimmune Diseases and a Review of Dual- and Single-Target Inhibitors

August 13, 2025

8 min read

A New Era in Targeted Therapies: Ichnos Glenmark Innovation and AbbVie Blaze a Trail with Tri-specific Antibodies

July 29, 2025

3 min read

KACTUS Unveils Ultra-low Endotoxin Recombinant Protein Line — Powering Cleaner, Faster, Smarter Drug Discovery

July 10, 2025

1 min read

Why Endotoxin Testing Matters: Safeguarding Recombinant Protein Applications in Immunology and Drug Discovery

May 22, 2025

4 min read

MASP2 Antibody Successful in Phase III Clinical Trial

February 10, 2025

5 min read

1 2 3
Nanodiscs: A Versatile Platform for Membrane Protein Research

April 28, 2025

8 min read

Addressing Challenging Antibody Discovery Targets with Virus-like Particle (VLP) Transmembrane Proteins

October 2, 2024

5 min read

Virus-like Particles: What they are and what they can o in Antibody Discovery

August 28, 2024

6 min read

Rewriting Life's Code: CRISPR Precisely Edits Blood Disorder Defects

August 5, 2025

3 min read

AAV Capsid Optimization and Precision Quantification: Customized AAV ELISA Detection Solutions

June 4, 2025

2 min read

Ensuring Safe and Effective Gene Therapy with Precise AAV Capsid Quantification

March 25, 2025

6 min read

Breaking News: KACTUS GMP-Grade Cas9 Powers Bioheng’s Breakthrough IND Clearance for Next-Gen UCAR-T Therapy

March 5, 2025

4 min read

Effective Serratia marcescens Nuclease for DNA & RNA Removal: MaxNuclease™

February 21, 2025

3 min read

Panorama of CRISPR Gene Editing Clinical Applications: 2024 Review

January 31, 2025

8 min read

NK Cell Therapy Gets IND FDA Clearance with AccuBase® Base Editor from KACTUS

November 21, 2024

5 min read

2024 Milestones in CRISPR Clinical Pipelines

November 11, 2024

5 min read

Base Editing vs. CRISPR: Navigating Precision Gene Therapy

October 14, 2024

5 min read

AccuBase™ Base Editor Continues to Advance NK Cell Therapies

July 31, 2024

4 min read

IND Approval for Solid Tumor Therapy Using KACTUS Cas9 Enzyme

July 24, 2024

4 min read

Gene Editing Drugs from the EMA Review Perspective

June 25, 2024

5 min read

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