Name: GMP Human IL-7 (GMP-CKS-HE007)
Brand: KactusBio
SKU: GMP-CKS-HE007-50UG
Price: 440.0 USD
Availability: InStock

Catalog #GMP-CKS-HE007

Size

50UG

50UGX10

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GMP Human IL-7 (GMP-CKS-HE007) Summary

Product Description	Recombinant GMP Human IL-7 is expressed from E.coli without tag.It contains Asp26-His177.
Product Background	Interleukin (IL)-7 is a non-redundant cytokine in T-cell development and function. It is required in early T-cell development as well as for T-cell homeostasis and is secreted by stromal cells in the thymic and bone marrow (BM) environment. IL-7 binds to its receptor which is composed of the two chains IL-7Rα (CD127), shared with the thymic stromal lymphopoietin (TSLP), and the common γ chain (CD132) for IL-2, IL-15, IL-9 and IL-21. Whereas γc is expressed by most hematopoietic cells, IL-7Rα is nearly exclusively expressed on lymphoid cells. After binding to its receptor, IL-7 signals through two different pathways: Jak-Stat (Janus kinase-Signal transducer and activator of transcription) and PI3K/Akt responsible for differentiation and survival, respectively.
Product Category	Recombinant Protein / Cell therapy / Cell culture / Cytokines

GMP Human IL-7 (GMP-CKS-HE007) Specifications/Details

Protein	IL-7
Synonyms	IL7; Interleukin-7; IL-7; Lymphopoietin-1; PBGF
Accession	P13232
Species	Human
Biotinylated	no
Amino Acid Range	Asp26-His177
Molecular Weight	The protein has a predicted MW of 17.5 kDa same as Bis-Tris PAGE result.
Product Tag	No Tag
Expression System	E.coli
Purity	≥ 95% as determined by SEC-HPLC.
Endotoxin	≤ 0.01 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Please refer to the Certificate of Analysis for detailed instructions.
Stability And Storage	The product is shipped with ice bag. Store it immediately at -20°C±5°C upon arrival. ；-20°C±5°C for 36 months in lyophilized state. ；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	GMP Human IL-7 on Bis-Tris PAGE under reduced condition.
	Measured in a cell proliferation assay using PHA-activated human peripheral blood mononuclear cell (PBMC). The specific activity of GMP Human IL-7 is > 1 × 10^8-IU/mg, which is calibrated against the human IL-7 WHO reference standard (NIBSC code: 90/530) (QC Test).