Mouse Noggin Protein (NOG-MM001)

  • Express System: HEK293
  • Product Tag: No Tag
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gln28-Cys232

Catalog: NOG-MM001


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Product Description Recombinant Mouse Noggin Protein is expressed from HEK293 without tag.It contains Gln28-Cys232.

Product Background

Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt.

Product Category

Recombinant Protein





Amino Acid Range

Molecular Weight The protein has a predicted MW of 23.07 kDa. Due to glycosylation, the protein migrates to 28-33 kDa based on Tris-Bis PAGE result.

Product Tag

No Tag

Express System

Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 0.1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS, 100mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 4-80 ng/mL in the presence of 50 ng/mL of recombinant Human BMP‑4.
The purity of Mouse Noggin is greater than 95% as determined by SEC-HPLC.
Mouse Noggin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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