Name: Mouse Noggin Protein (NOG-MM001)
Brand: KactusBio
SKU: NOG-MM001-100UG
Price: 345.0 USD
Availability: InStock

Express System: HEK293
Product Tag: No Tag
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Gln28-Cys232

Catalog #NOG-MM001

Size

100UG

500UG

1MG

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Product Description	Recombinant Mouse Noggin Protein is expressed from HEK293 without tag.It contains Gln28-Cys232.
Product Background	Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt.
Product Category	Recombinant Protein

Target	Noggin
Accession	P97466
Species	Mouse
Biotinylated	no
Amino Acid Range	Gln28-Cys232
Molecular Weight	The protein has a predicted MW of 23.07 kDa. Due to glycosylation, the protein migrates to 28-33 kDa based on Bis-Tris PAGE result.
Product Tag	No Tag
Express System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS, 100mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Mouse Noggin on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 4-80 ng/mL in the presence of 50 ng/mL of recombinant Human BMP‑4.
	The purity of Mouse Noggin is greater than 95% as determined by SEC-HPLC.

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