Mouse TPO/Thrombopoietin Protein (TPO-MM102)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Ser22-Thr356
Catalog #TPO-MM102
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Product Description
 Recombinant Mouse TPO/Thrombopoietin Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser22-Thr356.
Product Background
 Thrombopoietin (TPO), the c-Mpl ligand, is produced constitutively in liver and other organs, circulates in the bloodstream, and is delivered to bone marrow, where it stimulates the early development of multiple hematopoietic lineages and megakaryocytopoiesis. The concentration of TPO in blood is regulated by c-Mpl mass on platelets and megakaryocytes.
Product Category
 Recombinant Protein
Target
 TPO/Thrombopoietin
Synonyms
 Thrombopoietin; TPO; MGDF; THPO; ML; C-mpl ligand
Accession
Species
 Mouse
Biotinylated
 no
Amino Acid Range
 Ser22-Thr356
Molecular Weight
 The protein has a predicted MW of 37.20 kDa. Due to glycosylation, the protein migrates to 75-95 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse TPO on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 0.4-2.4 ng/ml (QC Test).
The purity of Mouse TPO is greater than 95% as determined by SEC-HPLC.

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