Biotinylated Human Activin RIIA/ACVR2A-Protein (ARA-HM52AB)

  • Express System: HEK293
  • Product Tag: C-hFc-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Biotinylated: yes
  • Activity: Immobilized Human Activin A, No Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Activin RIIA, hFc Tag with the EC50 of 17.1ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Ala20-Pro135

Catalog: ARA-HM52AB

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Product Description Recombinant Biotinylated Human Activin RIIA/ACVR2A-Protein is expressed from HEK293 with hFc tag and Avi tag at the C-terminus.It contains Ala20-Pro135.

Product Background

Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.

Product Category

Recombinant Protein

Target

Activin RIIA/ACVR2A

Gene/Protein ID

P27037-1

Species

Human

Exact Sequence

Ala20-Pro135
Molecular Weight The protein has a predicted MW of 41.16 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human Activin A, No Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Activin RIIA, hFc Tag with the EC50 of 17.1ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-hFc-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Activin A, No Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Activin RIIA, hFc Tag with the EC50 of 17.1ng/ml determined by ELISA.
The purity of Biotinylated Human Activin RIIA is greater than 95% as determined by SEC-HPLC.
Biotinylated Human Activin RIIA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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