Human ACVR1B/Activin RIB Protein (ALK-HM204)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: The affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Ser24-Glu126
Catalog #ALK-HM204
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Product Description
 Recombinant Human ACVR1B/Activin RIB Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ser24-Glu126.
Product Background
 Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system.
Product Category
 Recombinant Protein
Target
 ACVR1B/Activin RIB
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Ser24-Glu126
Molecular Weight
 The protein has a predicted MW of 37.36 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
 C-hFc
Express System
 HEK293
Purity
 >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human ACVR1B, hFc Tag captured on CM5 Chip via Protein A can bind Human TDGF1, His Tag-with an affinity constant of 0.16 uM as determined in SPR assay (Biacore T200).
Human ACVR1B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human ACVR1B is greater than 95% as determined by SEC-HPLC.
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