Product Description |
Recombinant Human ACVR1B/Activin RIB Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ser24-Glu126. |
Product Background |
Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system. |
Product Category |
Recombinant Protein |
Target |
ACVR1B/Activin RIB |
Synonyms |
ACVR1B; ACTR-IB; ALK 4; ALK-4; SKR2; ACVRLK4; ALK4; Activin R1B |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ser24-Glu126 |
Molecular Weight |
The protein has a predicted MW of 37.36 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human ACVR1B, hFc Tag captured on CM5 Chip via Protein A can bind Human TDGF1, His Tag-with an affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). |
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Human ACVR1B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human ACVR1B is greater than 95% as determined by SEC-HPLC. |
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