- Express System: HEK293
- Product Tag: C-hFc
- Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
- Activity: The affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). See testing image for detail.
- Amino Acid Range: Ser24-Glu126
Product Description |
Recombinant Human ACVR1B/Activin RIB Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ser24-Glu126. |
Product Background |
Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system. |
Product Category |
Recombinant Protein |
Target |
ACVR1B/Activin RIB |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ser24-Glu126 |
Molecular Weight |
The protein has a predicted MW of 37.36 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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