GMP Human IL-21 (GMP-CKS-HE021)
  • Express System: E.coli
  • Product Tag: No Tag
  • Purity: ≥ 95% as determined by SEC-HPLC.
  • Amino Acid Range: Gln32-Ser162
Catalog #GMP-CKS-HE021
Regular price $400.00
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Product Description

Recombinant GMP Human IL-21 is expressed from E.coli with without tag.It contains Gln32-Ser162.

Product Background

Interleukin- (IL-) 21 is a pleiotropic cytokine that regulates the activity of both innate and specific immunity. Indeed, it costimulates T and natural killer (NK) cell proliferation and function and regulates B cell survival and differentiation and the function of dendritic cells. In addition, IL-21 exerts divergent effects on different lymphoid cell leukemia and lymphomas, as it may support cell proliferation or on the contrary induce growth arrest or apoptosis of the neoplastic lymphoid cells.

Product Category

Recombinant Protein / Cell therapy / Cell culture / Cytokines

Protein

IL-21

Synonyms

Interleukin-21; IL-21; Za11; CVID11

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Gln32-Ser162

Molecular Weight

The protein has a predicted MW of 15.4 kDa same as Bis-Tris PAGE result.

Product Tag

No Tag

Expression System

E.coli

Purity

≥ 95% as determined by SEC-HPLC.

Endotoxin

≤ 0.01 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
The product is shipped with ice bag. Store it immediately at -20°C±5°C upon arrival.;-20°C±5°C for 36 months in lyophilized state.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
GMP Human IL-21 on Bis-Tris PAGE under reduced condition. GMP Human IL-21 on Bis-Tris PAGE under reduced condition.
Measured by its activity to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is ≤ 8 ng/mL. The specific activity of GMP Human IL-21 is > 1 × 10^5-U/mg (QC Test). Measured by its activity to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is ≤ 8 ng/mL. The specific activity of GMP Human IL-21 is > 1 × 10^5-U/mg (QC Test).

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