GMP Human IL-21 (GMP-CKS-HE021)
  • Express System: E.coli
  • Product Tag: No Tag
  • Purity: ≥ 95% as determined by SEC-HPLC.
  • Amino Acid Range: Gln32-Ser162
Catalog #GMP-CKS-HE021
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Size
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GMP Human IL-21 (GMP-CKS-HE021) Summary

Product Description

 Recombinant GMP Human IL-21 is expressed from E.coli without tag.It contains Gln32-Ser162.

Product Background

 Interleukin- (IL-) 21 is a pleiotropic cytokine that regulates the activity of both innate and specific immunity. Indeed, it costimulates T and natural killer (NK) cell proliferation and function and regulates B cell survival and differentiation and the function of dendritic cells. In addition, IL-21 exerts divergent effects on different lymphoid cell leukemia and lymphomas, as it may support cell proliferation or on the contrary induce growth arrest or apoptosis of the neoplastic lymphoid cells.

Product Category

 Recombinant Protein / Cell therapy / Cell culture / Cytokines

GMP Human IL-21 (GMP-CKS-HE021) Specifications/Details

Protein
 IL-21
Synonyms
 Interleukin-21; IL-21; Za11; CVID11
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gln32-Ser162
Molecular Weight
 The protein has a predicted MW of 15.4 kDa same as Bis-Tris PAGE result.
Product Tag
 No Tag

Fluorophore

 Unconjugated
Expression System
 E.coli
Purity
 ≥ 95% as determined by SEC-HPLC.
Endotoxin
 ≤ 0.01 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Stability And Storage
 The product is shipped with ice bag. Store it immediately at -20°C±5°C upon arrival.；-20°C±5°C for 36 months in lyophilized state.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

GMP Human IL-21 on Bis-Tris PAGE under reduced condition. GMP Human IL-21 on Bis-Tris PAGE under reduced condition.
Measured by its activity to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is ≤ 8 ng/mL. The specific activity of GMP Human IL-21 is > 1 × 10^5-U/mg (QC Test). Measured by its activity to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is ≤ 8 ng/mL. The specific activity of GMP Human IL-21 is > 1 × 10^5-U/mg (QC Test).
Other Available Proteins:
Finding available proteins...
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