Human/Cynomolgus Activin RIIA/ACVR2A-Protein (ARA-HM32A)
  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human/Cynomolgus Activin RIIA, mFc Tag with the EC50 of 7.4ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Ala20-Pro135
Catalog #ARA-HM32A
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Product Description
 Recombinant Human/Cynomolgus Activin RIIA/ACVR2A-Protein is expressed from HEK293 with mFc (IgG1) tag at the C-terminus.It contains Ala20-Pro135.
Product Background
 Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
Product Category
 Recombinant Protein
Target
 Activin RIIA/ACVR2A
Synonyms
 ACTR-IIA; ACTRIIA; ACVR2A; ACVR2
Accession
Species
 Human/Cynomolgus
Biotinylated
 no
Amino Acid Range
 Ala20-Pro135
Molecular Weight
 The protein has a predicted MW of 39.07 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human/Cynomolgus Activin RIIA, mFc Tag with the EC50 of 7.4ng/ml determined by ELISA. See testing image for detail.
Product Tag
 C-mFc
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human/Cynomolgus Activin RIIA, mFc Tag with the EC50 of 7.4ng/ml determined by ELISA.
Human/Cynomolgus Activin RIIA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human/Cynomolgus Activin RIIA is greater than 95% as determined by SEC-HPLC.

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