Human Activin RIIB/ACVR2B Protein (ARB-HM32B)

  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Activin A, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIB, mFc Tag with the EC50 of 41.4ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Ser19-Thr137

Catalog: ARB-HM32B

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Product Description Recombinant Human Activin RIIB/ACVR2B Protein is expressed from HEK293 with mFc (IgG1) tag at the C-terminus.It contains Ser19-Thr137.

Product Background

ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myostatin (MSTN), growth differentiation factor 11 (GDF11), and bone morphogenetic protein 9 (BMP9).

Product Category

Recombinant Protein

Target

Activin RIIB/ACVR2B

Gene/Protein ID

Q13705-1

Species

Human

Exact Sequence

Ser19-Thr137
Molecular Weight The protein has a predicted MW of 39.32 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human Activin A, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIB, mFc Tag with the EC50 of 41.4ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-mFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Activin A, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIB, mFc Tag with the EC50 of 41.4ng/ml determined by ELISA.
The purity of Human Activin RIIB is greater than 95% as determined by SEC-HPLC.
Human Activin RIIB on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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