Product Description |
Recombinant Human Osteoactivin/GPNMB Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Lys23-Asn486. |
Product Background |
GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively. Some studies have shown increased levels of GPNMB in pro-inflammatory conditions, such as LPS treatment, and in pathological conditions, such as neurodegenerative diseases and cancer. |
Product Category |
Recombinant Protein |
Target |
Osteoactivin/GPNMB |
Synonyms |
GPNMB; HGFIN; NMB; Osteoactivin |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Lys23-Asn486 |
Molecular Weight |
The protein has a predicted MW of 53.1 kDa. Due to glycosylation, the protein migrates to 78-98 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human Osteoactivin on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human Osteoactivin is greater than 95% as determined by SEC-HPLC. |
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