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Non-biotinylated Human FGFR4 Protein (FGF-HM4R4) Summary
Product Description |
Recombinant Human FGFR4 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu22-Asp369. |
Product Background |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Non-biotinylated Human FGFR4 Protein (FGF-HM4R4) Specifications/Details
Protein |
FGFR4 |
Synonyms |
CD334; FGF R4; FGFR4; FGFR-4; MGC20292; JTK2; TKF |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Leu22-Asp369 |
Molecular Weight |
The protein has a predicted MW of 41.4 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human FGFR4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human FGFR4 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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