Name: Cynomolgus GDF15 Protein (GDF-CE115)
Brand: KactusBio
SKU: GDF-CE115-100UG
Price: 315.0 USD
Availability: InStock

Express System: E.coli
Product Tag: N-His
Purity: >95% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus GDF15, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Arg193-Val308

Catalog #GDF-CE115

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus GDF15 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Arg193-Val308.
Product Background	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
Product Category	Recombinant Protein / Antibody discovery

Protein	GDF15
Synonyms	GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β
Accession	G7PWZ3
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Arg193-Val308
Molecular Weight	The protein has a predicted MW of 14.15 kDa. The protein migrates to 15-18 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus GDF15, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	N-His
Expression System	E.coli
Purity	>95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in 50mM HAc (pH 2.9). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 50mM HAc (pH 2.9).
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus GDF15, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA (QC Test).
	Immobilized Cynomolgus GDF15, His Tag at 0.2 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC50 of 6.1 ng/ml determined by ELISA.
	Cynomolgus GDF15 on Bis-Tris PAGE under reduced (R) condition and Non reducing (N) condition. The purity is greater than 95%.