• Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Amino Acid Range: Phe24-Gly1012 (ITGA6) acidic tail & GIn21-Asp728 (ITGB1) basic tail
Catalog #ITG-HM461
Price
Regular price $41250
Regular price Sale price $41250
/
Size
Avantor VWR Fisher Scientific

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Non-biotinylated Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein (ITG-HM461) Summary

Product Description

 Recombinant Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGA6.It contains Phe24-Gly1012 (ITGA6) acidic tail and GIn21-Asp728 (ITGB1) basic tail.

Product Background

 Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling

Non-biotinylated Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein (ITG-HM461) Specifications/Details

Protein
 Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer
Synonyms
 α6β1; Integrin alpha 6 beta 1; ITGA6&ITGB1;Integrin alpha 6 β 1;a6b1; alpha 6 beta 1; Integrin alpha 6 b 1; Integrin alpha 6b1
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Phe24-Gly1012 (ITGA6) acidic tail & GIn21-Asp728 (ITGB1) basic tail
Molecular Weight
 The protein has a predicted MW of 117.9 kDa (ITGA6) and 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reduced (N) condition based on Bis-Tris PAGE result.
Product Tag
 C-His-Avi
Fluorophore
 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
 -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human ITGA6&ITGB1 on Bis-Tris PAGE under Non reduced (N) condition. The purity is greater than 95%. Human ITGA6&ITGB1 on Bis-Tris PAGE under Non reduced (N) condition. The purity is greater than 95%.
Other Available Proteins:
Finding available proteins...