Name: Human IgG1 Fc Protein (IGG-HM001)
Brand: KactusBio
SKU: IGG-HM001-100UG
Price: 82.5 USD
Availability: InStock

Express System: HEK293
Product Tag: No Tag
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.28 uM as determined in SPR assay (Biacore T200).
Amino Acid Range: Asp104-Lys330

Catalog #IGG-HM001

Size

100UG

500UG

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Human IgG1 Fc Protein (IGG-HM001) Summary

Product Description	Recombinant Human IgG1 Fc is expressed from HEK293 without tag.It contains Asp104-Lys330.
Product Background	IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues.IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Product Category	Recombinant Protein / Antibody discovery / Fc receptors

Human IgG1 Fc Protein (IGG-HM001) Specifications/Details

Protein	IgG1 Fc
Synonyms	IgG1; Igh-4; RGD1359539; VH7183
Accession	P01857-1
Species	Human
Biotinylated	no
Amino Acid Range	Asp104-Lys330
Molecular Weight	The protein has a predicted MW of 25.5 kDa. Due to glycosylation, the protein migrates to 31-33 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 0.28 uM as determined in SPR assay (Biacore T200).
Product Tag	No Tag
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human FcRn, His Tag captured on CM5 Chip via anti-his antibody can bind Human IgG1 Fc, No Tag with an affinity constant of 0.28 uM as determined in SPR assay (Biacore T200).
	Human IgG1 Fc on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Biotinylated Human FcRn, His-Avi Tag on Streptavidin-Biosensor can bind Human IgG1 Fc, No Tag with an affinity constant of 22.8 nM as determined in BLI assay .
	The purity of Human IgG1 Fc is greater than 95% as determined by SEC-HPLC.

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